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mifepristone will improve the stage or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.iloperidone boosts levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Iloperidone is a time-dependent CYP3A inhibitor and could lead to increased plasma level